Adults 18 years of age and older with solid tumors or lymphomas that have advanced following at least one line of standard systemic therapy, or with tumors for which there is no standard treatment, will be eligible. Each arm of the trial will enroll up to 35 patients. The trial's design calls for at least a quarter of the 1,000-patients enrolled to involve people with rare types of cancer. "After starting treatment in NCI-MATCH, a 6-month progression-free survival of 15 percent will not be considered promising, whereas a progression-free survival at six months of 35 percent will indicate that we would want to develop that treatment further."

Sonya Zalubowski writes: We saw all of the 'Big Five' on our safari. I never knew exactly what they were and what the term meant, 'the five most dangerous animals to hunt on foot in Africa'. They include the Cape buffalo, the elephant, the leopard, the lion and the now rare black rhino, hunted for its horn, prized in Asia as a medicine. The Maasai tribe and the wild animals and yes, we, the tourists, manage to continue in all of our ways, though there is controversy over how long this can go on as human population grows and further encroaches on the wild animals of Africa.

Connivers for riches or for the love of someone promised to another are sure to be ruined by evil envy, just as the person envied will win out, get the prince, win the princess. As we read fairy tales we see ourselves as we are and as we should be. Envy is interpreted by multimedia artist Adrien Broom in photographs and life-sized scenes from fairy tales, the stories of passion, evil and redemption. At the Hudson River Museum, don't over look the Nybelwyck House or the Red Grooms Bookstore installation.

Almost two-thirds of the states are punishing tax delinquents with a digital version of the Colonial practice of locking lawbreakers in stocks set up in the village square. It turns out publishing the names of tax scofflaws and the amounts they owe on the Internet works spectacularly well, bringing in millions to states eager for the revenue. "When you are talking about large debts, you do tend to get some people who just don?t care. It's just not worth playing off their $450,000 or $1.2 million debt. Down on the lower levels, you get more of the Average Joe who is concerned."

"Girls Count" Legislation: The bill finds lack of birth registration for girls can exacerbate women's and girls' vulnerability to trafficking, child marriage, lack of access to health and education services, reduced unemployment. House Appropriations urges DoJ to combat cyber-stalking and is concerned with ongoing sexual assault kit backlogs. House Veterans Affairs approved the Ruth Moore Act, and a bill to provide counseling services for women veterans. "GAO found that USDA had not specifically directed states to tell participants that selling WIC formula was a participant violation."

Roberta McReynolds Updates: I rescued a fledging sparrow about a month ago. It had been attacked by a Scrub Jay and I literally snatched it away. Poor little thing was in shock and bleeding from her beak. I would have bet money that she was going to die within minutes. I wrapped her in a towel and warmed her up. After an hour she was still hanging in there. I found a box and lined it with more towels and tucked her inside, warming the outside of the box with one of those gizmos you heat in the microwave. She survived the night!

40 maps that explain outer space; For those interested in STEM education, there is much to ponder on an interesting site; Video clips accompany many of the Timeline items, bringing the history of WWI to life. The Edublogger, which serves as the community blog for Edublogs and CampusPress, is designed to help educational bloggers with emerging technologies; Companion piece to the Women's Adventures in Science biography series; Browse the Darwin Manuscripts Tree, a visual representation of his theories; Longform connects readers to new and classic non-fiction from around the web; Wix.com is one of the most popular website builders on the market ... and others. Enjoy!

An evening phone call to my post-surgery friend confirms he is managing okay. The painkillers are doing their job and he is comfortable watching television. "Thanks for being there for me," he says... I had been certain my nightly routine would seal my husband in my brain. Every night before I go to sleep, I say, "Love you, Tommy" to the pillow I use as his stand-in. And I hear back, clear as if he were at my left instead of his surrogate, "Love you, too!" ...That's when I realized how much I had come to adore my new place, which has quickly become a refuge and cocoon cushioning me from the sad events that propelled me to this new life. How could I ever leave this solace?

The Wellcome Trust Sanger Institute study revealed that each cell in normal facial skin carries many thousands of mutations, mainly caused by exposure to sunlight. Around 25 per cent of skin cells in samples from people without cancer were found to carry at least one cancer-associated mutation. The mutations observed showed the patterns associated with the most common and treatable form of skin cancer linked to sun exposure, known as cutaneous squamous cell carcinoma, rather than melanoma, a rarer and sometimes fatal form of skin cancer.

"We are experiencing the greying of America, with 45 million people in this country who are age 65 or older and 10,000 more who are turning 65 each day. They are our grandparents, our parents, our neighbors, our friends. The average American is now spending about twenty years in retirement. They are still taking out and making payments on mortgages; they are still borrowing to buy cars and trucks; they are still accumulating credit card debt; some are even taking out student loans on behalf of their grandchildren. These heavier debt loads, that previous generations did not have, can threaten their economic security.

Joan L. Cannon writes: That summer, I was staying in the country with a recently widowed friend. She was aware that the previous winter I'd broken an engagement with a college classmate and had emerged a bit emotionally bruised. Having more or less sworn off men for the time being, I reluctantly agreed to her suggestion, feeling assured that he wouldn't accept anyway. He'd shown no particular interest in me before, other than displaying very pleasant manners. He accepted.  

  Takata files defect reports, enters Consent Order; NHTSA to coordinate remedy program US Transportation Secretary Anthony Foxx today announced that at the Department?s insistence, air bag manufacturer Takata has acknowledged that a defect exis…

"These funds are the cornerstone of state-based efforts that are critical to the preservation of America's wildlife and natural resources," said Service Director Dan Ashe. "But they are also the fuel for a massive financial engine that benefits outdoor recreationists, hunters, boaters and anglers, equipment manufacturers and retailers, and local and regional economies. Their value cannot be overstated in providing opportunities for the next generation of Americans to get outdoors, experience our wild places and learn the importance of conserving our natural heritage."

The Helhesten and the Danish Avant-Garde exhibition exploring how and why European modern art was made during the rise of Fascism, includes 120 paintings, works on paper and sculptures by artists. The second exhibit showcases the rich artistic traditions of Mexico and the passionate and patriotic pride of its artists, the exhibition features masterworks by Kahlo and Rivera along with paintings, sculptures and works on paper by other influential Mexican artists involved in the country's political and social struggles.

The exhibition presents the many devices and materials that women and men have used to shape their silhouettes from the seventeenth century to today, including panniers, corsets, crinolines, bustles, stomach belts, girdles, and push-up brassieres. The exhibition will also look at how lacing, hinges, straps, springs, and stretch fabrics have been used to alter natural body forms. In men's fashion, the exhibition explores how padded jackets provoked arched torsos; how calf enhancers, stomach belts, and codpieces were worn; and how variations on these enhancements continued into the nineteenth century and beyond.

"Secretary McDonald should be front and center with a response to every report of mismanagement at the Veterans Affairs. He should present Congress, taxpayers, and most of all veterans, with a clear, concise, and comprehensive plan to cut the waste, fraud, and abuse and improve the efficiency and effectiveness of the VA. Instead, he has not exactly elicited the kind of empathy on Capitol Hill that would help him acquire the necessary tools to fix the agency's problems."

Julia Sneden wrote: I once had the father of a 5-year-old ask me: "On a scale of 1-10, how would you rate my daughter?" When I protested that I wasn't in the business of rating kindergarten children, he persisted: "But if you were? Where would you put her?" "As compared to what or whom?" I asked. "As compared to her academic potential? Her social skills? Her satisfactoriness as a daughter? Her athletic ability?" "You know what I mean," he said. "Compared to the rest of your class, 1-10, where does she stand?" There seemed to be no point in giving a serious answer to something like that, and I gave him what he wanted to hear. "She's a 10, of course," I said cheerfully. And mentally I added: "And you, sir, are a minus 3."

In 21 states, employment has increased less than 7 percent. But in other states, employment has bounced back strongly: In 14, employment has increased 10 percent or more since their low points. North Dakota has led the way thanks to its oil boom. Other top performers are Texas and Utah, where employment has increased more than 15 percent since December 2009 and February 2010, respectively. Next are California and Colorado, where employment is up more than 13 percent since their lowest points in early 2010.       May 13, 2015  By Jake Grovum © AP Although the nation?s unemployment rate is at a seven-year low of 5.4 percent, job growth among the states has been uneven, with several showing…

Religious intermarriage appears to be on the rise: Among Americans who have gotten married since 2010, nearly four-in-ten (39%) report that they are in religiously mixed marriages, compared with 19% among those who got married before 1960. Nearly 1-in-5 people surveyed who got married since 2010 are either religiously unaffiliated respondents who married a Christian spouse or Christians who married an unaffiliated spouse. Just 5% of people who got married before 1960 fit this profile.

Which two first ladies met their husbands through local newspapers? Who was the first First Lady to make regular nationwide radio broadcasts? Which First Lady cared for wounded soldiers in her husband's command? Who was originally a Broadway actress before becoming the First Lady? If you're looking to learn more about the past First Ladies who have helped lead our country, you're in the right place. Take a look at our full set of biographies. Then, quiz your friends.

Nancy Scheper-Hughes gave two presentations at a human-trafficking plenary in Rome and says her primary contributions came in proposals relating to organ trafficking. One would prohibit "the buying, selling, brokering and implanting of organs and tissues from trafficking persons in all countries." Another would ask the world?s religions to encourage voluntary and altruistic organ sharing. "In the end, clothes did not make either the man or the woman. Gender still remained highly marked, and many clerics at Santa Marta [the Pope's residence] were uncomfortable sharing a communal table with a woman, let alone talking to her."

From a NYT's Editorial: The libraries are where poor children learn to read and love literature, where immigrants learn English, where job-seekers hone résumés and cover letters, and where those who lack ready access to the Internet can cross the digital divide. They are havens for thinking, dreaming, studying, striving and ? for many children and the elderly ? simply for staying safe, and out of the heat.

Ferida Wolff writes: Our periwinkle has blossomed again, as it does each year, a groundcover that takes its mission seriously. Last year we planted four different kinds of tomatoes and feasted on red, yellow, and mottled varieties. We also set up a small greenhouse that had a way of breaking loose from its boundaries despite the spikes we used to hold it down. It flipped over uprooting our peas and beans but the tomato plants were least affected. We couldn't figure out if an animal pushed it over or some of the neighborhood kids were having fun but it isn't going back up this season.

Drs. Groopman and Hartzband (also husband and wife) reveal that each of us has a 'medical mind,' a highly individual approach to weighing the risks and benefits of treatment. Are you a minimalist or a maximalist, a believer or a doubter, do you look for natural healing or the latest technology? Drs. Groopman and Hartzband explain how pitfalls in thinking and the way statistics are presented in pharmaceutical advertisements, the media, and even scientific reports can mislead all of us. Streaming at NCCIH and a YouTube at the Aspen Institute.