Beyond the general critique of careless interpretations of seemingly sexy study findings, the authors make a subtler point about clinical trials. They screened 92 potential participants for the study, but only 23 were eligible and willing to participate. The authors suggest that this resembles common practice in clinical trials, where a small fraction of the patients screened are included. They add that prior research shows participants who might stand to gain the most from the experimental treatment often are less likely to be included in clinical trials.

In a series of interviews with heroin users in Rhode Island in 2017, Brown University researchers reported that users ?described fentanyl as unpleasant, potentially deadly, and to be avoided.? They concluded that demand for the deadly contaminant was low and that its presence in the drug supply was ?generating user interest in effective risk mitigation strategies, including treatment.? But in San Francisco?s gritty Tenderloin district, where fentanyl was only rarely seen until last year, drug users tell a starkly different story. For many of them, fentanyl is a high-value drug that, if used carefully, can prevent dope sickness and deliver a strong high for a fraction of the price of heroin. Amber Sheldon, right, greets a frequent client at the harm reduction program at Glide in San Francisco. The program offers clean syringes, drug tes…

Sonya Zalubowski writes: One of the most thrilling moments was our visit to the Alcazar in Segovia, the castle with foundations that date to Roman times, where Isabella and Ferdinand reigned in the 15th century. We stood in the very throne room where Christopher Columbus once knelt before her. The people are surrounded by remnants of a succession of cultures ranging all the way back to prehistoric to Roman, Visigoth and Moorish, to the kings and queens whose rule dominated Europe as they sent out Portuguese and Spanish explorers, to 20th-century despots and finally present day governments

While it is certainly admirable to pay off your mortgage before you retire, our experience is that retirees and pre-retirees over-estimate the impact. In today?s world of low mortgage rates, paying off the last $100,000 of your mortgage, may free up cash flow, but isn?t saving you much in interest cost. You are still left with paying insurance, and property taxes, which will continue to go up. If you consider the fact that the IRS allows for a building to depreciate over 27.5 years, it stands to reason that you may need to almost completely replace your home over 25-40 years. And if you are banking on your home to pay long-term care costs or for a move to a more elderly friendly environment, you might be disappointed in what you get.

Editor's Note: Two points about this lawsuit are it doesn't force an injunction and doesn't protect private contractors. "Our members put their lives on the line to keep our country safe,? said J. David Cox Sr., national president, American Federation of Government Employees, ?requiring them to work without pay is nothing short of inhumane. Positions that are considered ?essential? during a government shutdown are some of the most dangerous jobs in the federal government. They are frontline public safety positions, including many in law enforcement, among other critical roles. A substantial number of those working without pay are military veterans."

New York City's Metropolitan Museum of Art exhibition (Floor 2, Gallery 999, Iris and B. Gerald Cantor Exhibition Hall) opens with a dramatic installation that emphasizes the universality of jewelry ? precious objects made for the body, a singular and glorious setting for the display of art. Great jewelry from around the world will be presented in a radiant display that groups these ornaments according to the part of the body they adorn: head and hair; nose, lips, and ears; neck and chest; arms and hands; and waist, ankles, and feet.

Julia Sneden wrote: It's embarrassing to think back over the sheer volume of presents I've received over the years. A few stand out: a beautiful, winter-white skirt of soft wool embroidered with pale blue and silver snowflakes that I longed for but knew we couldn't afford, that turned up miraculously anyway ... an opal ring that my great aunt had promised me when I was sixteen ... from my husband, a pair of books by Carmen Bernos de Gasthold, the first Christmas we were married ... a present my eldest son selected all by himself for me when he was about eight, blue ornament earrings paid for from his allowance ... the Double Crostic books another son gives me yearly ... a copy of Babar the King brought me by my adult middle son ... photos of my grandchildren taken and compiled into a little book by my clever daughter-in-law.

During the holidays, many in the press write stories aiming to help readers cope with the blues and other seasonal conditions. But some journalists inadvertently support a myth about the holidays and suicide, or quote well-intentioned sources who should know better. Despite the fact that the holiday season has some of the lowest average daily suicide rates, some journalists continue to perpetuate the holiday-suicide myth. In the 2017-18 holiday season, two-thirds of the print news and feature stories that mentioned both the holidays and suicide drew a false connection between them, according to the latest analysis by the Annenberg Public Policy Center of the University of Pennsylvania.   

"Similarly, I believe we must be resolute and unambiguous in our approach to those countries whose strategic interests are increasingly in tension with ours. It is clear that China and Russia, for example, want to shape a world consistent with their authoritarian model ? gaining veto authority over other nations? economic, diplomatic, and security decisions ? to promote their own interests at the expense of their neighbors, America and our allies. ... We must do everything possible to advance an international order that is most conducive to our security, prosperity and values, and we are strengthened in this effort by the solidarity of our alliances."  

Compelled by personal financial difficulties, Dickens wrote A Christmas Carol in only six weeks, during a period of intense creativity in fall 1843. The original manuscript of A Christmas Carol reveals Dickens's method of composition, allowing us to see the author at work. The pace of writing and revision, apparently contiguous, is urgent, rapid, and boldly confident. And, if you want to make a full weekend of Dickens' story and have an Amazon Prime membership among others, view The Man Who Invented Christmas. Dickens is portrayed by Dan Stevens, of Downton Abbey fame. The program is also available for a minimum fee if you don't have one of the memberships.

?Many states have seen fewer births and more deaths in recent years,? said Sandra Johnson, a demographer/statistician in the Population Division of the Census Bureau. ?If those states are not gaining from either domestic or international migration they will experience either low population growth or outright decline.? Nationally, natural increase (the excess of births over deaths) was 1.04 million last year, reflecting 3,855,500 births and 2,814,013 deaths. With fewer births in recent years and the number of deaths increasing, natural increase has declined steadily over the past decade. In 2008, natural increase was nearly 1.8 million (based on National Center for Health Statistics data).

?While alerts in the entertainment sector are numerous (e.g. Clark Griswold illustrating risks such as burning down the Christmas tree, falling from the roof while installing Christmas lighting and being attacked by a squirrel hidden in the Christmas tree), serious health warnings are often ignored due to the preponderance of Christmas spirit.? Researchers also found that 277 children were hurt during interactions with a Santa impersonator ? for example, by falling off his lap or falling while running away in fear.

Joan L. Cannon wrote: I went to my own 40th high school reunion and my 50th college one. It was that one that made me swear off that kind of gathering. The first problem is that we know that we're in for surprises both pleasant and not so much. It seems these gatherings force an automatic exercise in comparisons. Every attendee has to face unstated competition as intense as that for college acceptance; it's just based on different criteria. How have I aged in appearance compared with my classmates? Can I match the average for marriage, number of children, implied income, social status, renown?  

Preventing veteran suicide is one of the Department of Veterans Affairs' highest priorities. VA reports that an average of 20 veterans die by suicide each day. Since 2010, VA has conducted national outreach to raise awareness about suicide prevention resources for veterans. However, we found that VA's outreach activities dropped off in 2017 and 2018, and the office responsible for these activities lacked consistent leadership. We also found that VA did not have clear goals for evaluating the effectiveness of its outreach activities.

Margaret Cullison writes: I suffered from cake envy after attending a friend?s birthday party when I was six or seven years old. She had an April birthday, and her cake that year looked like a lamb with white frosting and coconut curled fur. The cake completely enchanted me. I knew my friend?s mother hadn?t made the cake herself. We always had homemade birthday cakes at home, but that didn?t impress me nearly as much as the magic of Sandy?s lamb cake.

?Sexual harassment goes far beyond the cases you read in the headlines ? it?s not just about the rich and famous, but also the nurse, or the teacher, or the line worker at the factory. Today, Congress sent a message that workplace harassment of any kind is unacceptable,? Sen. Amy Klobuchar said. ?The time has come to stop protecting politicians and to start supporting victims. All men and women deserve a workplace free from harassment.? ?Today, the House and Senate came together to end a broken process that failed victims for far too long,? Sen. Roy Blunt said. ?This bipartisan, bicameral agreement will protect the rights of victims and ensure perpetrators are held accountable for conduct unacceptable in the Congress or any workplace. I thank Senator Klobuchar and House and Senate leadership for getting this bill through Congress and on its way to the president?s desk.?

As I'd watch each [friend] enter her kitchen, pull a mug from a cabinet, and pour her hot drink, I felt as if I had been reunited with a long-lost sister. But it wasn't DNA that matched us, simply years of traveling together through life's joys and sorrows. A trio of these friends had known me through first marriage and divorce, and all cleaved to me through my second husband's illness and death. We'd bring each other up-to-date on the goings on during the nearly five months since I departed from my longtime home. And even though I chat frequently with these friends, and view Facebook status reports, these early morning kitchen conversations were as precious as an heirloom.

President Trump clashes with House and Senate Democratic leaders Representative Nancy Pelosi and Senator Chuck Schumer over border security and government funding during an Oval Office meeting. As Senator Schumer termed it, 'a temper tantrum'. Rep. Nancy Pelosi referred to the looming government shutdown threatened by President Trump as a 'Holiday present for the American public from the President'.

David Westheimer wrote: It is October 1945. I am less than six months out of a Luftwaffe POW camp and my bride is coming out of more than a year of mourning for her first husband, a tank commander killed in action in Belgium who never saw their baby son. We have known each other forever. We were never introduced. She was the bratty little girl who was around when I visited her slightly older brother and sister. Her Uncle Louie wants to give us a honeymoon for a wedding present. Two weeks in New York, where I had never been.  

Rose Madeline Mula writes: It?s interesting to note that in some areas men are managing to withstand female infiltration. Doormen are still doormen, for example. I know that I, for one, have yet to see a door woman. Since Joan Rivers? failed foray into the arena, late-night TV hosts are still male. Since Oprah?s retirement, Ellen DeGeneres still rules the afternoon; but will we ever see a Stephanie Colbert or Jenny Kimmel after dark? Females, on the other hand, unfortunately, seem to have a lock on less prestigious, less lucrative careers.

Overall, the findings, just published in the journal Emotion, showed an increase in such positive behaviors as humor and affection and a decrease in negative behaviors such as defensiveness and criticism. The results challenge long-held theories that emotions flatten or deteriorate in old age and point instead to an emotionally positive trajectory for long-term married couples. ?Given the links between positive emotion and health, these findings underscore the importance of intimate relationships as people age, and the potential health benefits associated with marriage.?

Bills Introduced: Sen. Richard Blumenthal (D-CT)/Judiciary (11/29/18) ? A bill to make it a criminal offense for individuals to engage in sexual acts while acting under color of law or with individuals in their custody, to encourage states to adopt similar laws. A bill to provide coverage for custom fabricated breast prostheses following a mastectomy. A bill to allow the child tax credit with respect to stillbirths. The House Oversight and Government Reform Committee held a hearing, ?BOP [Bureau of Prisons] Management of its Female Inmate Population and Other Challenges.? The Senate Foreign Relations Committee approved the Women?s Entrepreneurship and Economic Empowerment Act, as amended.

Julia Sneden: We find that it an interesting process, looking back at books we read in our twenties and thirties. The books themselves haven't changed, but thanks to the varied experiences that another twenty or thirty years have added to our lives, we read them from a different perspective. Herewith, the first review of an old, beloved book (actually, three books):"'When you yourself had borne a child, Kristin, I thought you would understand,' her mother had said once. Now, she understood that her mother's heart had been scored deep with memories of her daughter, memories of thoughts for her child from the time it was unborn and from all the years a child remembers nothing of, memories of fear and hope and dreams that children never know have been dreamed for them, until their own time comes to fear and hope and dream in secret.'"    

The Bodleian exhibition aims to recreate Dickens?s world through these ephemeral items, taking visitors on a journey back to his time with themes such as Victorian London and its amusements, the coming of the railways, domestic entertainment and children?s school life. A number of Dickens's works have been recorded by the Libraries, bringing London to life. The Bodleian exhibition illustrates the relationship between the fictional worlds that Charles Dickens created in his novels and the historical reality in which he lived. He depicted the social realities of his time with what Henry James noted as his ?solidity of specification,? an extraordinary clarity and particularity. The actualities of life, especially life in London - the setting for almost all his fiction - were of singular importance to him. When we read Dickens we experience Victorian life.